The skin of the fruit contains a substance called Hydroxycitric Acid (HCA), which is the active ingredient. Does Garcinia Cambogia Actually Work.
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Woman Smiling and Holding a Supplement I managed to find several research studies on Garcinia Cambogia, in both animals and humans. According to some studies in rats, ills can inhibit a fat producing enzyme called Citrate Lyase, making it more difficult for the body to produce fat out of carbohydrates (1).
Other rat studies show increased levels of the neurotransmitter serotonin.
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This could theoretically lead to reduced appetite and cravings (2). There are actually a whole bunch of studies in rats showing that Garcinia Cambogia consistently leads to significant weight loss (3, 4, 5, 6).
However, what works in rats doesnt always work in humans.
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Bottom Line: Studies in rats show that the active ingredient in Garcinia Cambogia can inhibit a fat producing enzyme called Citrate Lyase and increase serotonin levels, leading to significant weight loss. A Look at Some Human Studies Fortunately, I also found several human studies on Garcinia Cambogia.
All of these studies are so-called randomized controlled trials, which are the gold standard of scientific experiments in humans.
The biggest of the studies included 135 overweight individuals, which were vipaine into two groups (7): Treatment group: 1 gram of Garcinia Cambogia Extract, 3 times per day, taken 30 minutes before meals.
Placebo group: The other group took dummy pills (placebo).
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Both groups also went on a high-fiber, low calorie diet. These were the results of the 12 week study, which was published in The Journal of The American Medical Association wt highly respected scientific journal): Heymsfield, et al.
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1998 As you can see, both vilaime lost weight. But the group taking Garcinia Cambogia extract actually lost less weight (3.
2 kg 7 pounds) than the placebo group (4. 1 kg 9 pounds). The researchers also looked at body fat percentage. The placebo group lost 2. 16, while the group taking Garcinia Cambogia lost only 1.
However, the difference was not statistically significant, meaning that the results could have been due to chance. More Studies In another study with 89 overweight females, Garcinia Cambogia did lead to 1.
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3 kg (2. 8 pounds) more weight loss compared to placebo, over a period of 12 weeks. They found no difference in appetite between groups (8).
Overall, I looked at 4 more studies. Two of them showed weight loss of a few pounds over a period of 8 weeks (9, 10), but the other two showed no effect (11, 12). So… unfortunately, the weight loss effects appear to be both weak and inconsistent.
A review published in the Journal of Obesity in 2011 that looked at 12 clinical trials found that Garcinia Cambogia can increase weight loss by about 0.
88 kg, or 2 pounds, on average, over a period of several weeks (13). Their conclusion sums it up quite nicely: …Garcinia extractsHCA can cause short-term weight loss.
The magnitude of the effect is small, and the clinical relevance is uncertain. I agree.
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